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The Scuppernong (vitis rotundifolia) is a variety of muscadine grape, and has the distinction of being the first grape ever actively cultivated in the United States.
It was named for the Scuppernong River, which runs from Washington County to the Albemarle Sound. Giovanni de Verrazano noticed this variety as far back as 1524, and explorers for Sir Walter Raleigh (or Ralegh, as it's sometimes spelled) in the 1580’s sent back reports from the Outer Banks of grape vines that “…covered every shrub and climbed the tops of high cedars. In all the world, a similar abundance was not to be found.”
They are also the state fruit of North Carolina.